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1: J Pharm Pharmacol. 2002 Feb;54(2):295-8.Click here to read Links

Identification of indolyl-3-acryloylglycine in the urine of people with autism.

Anderson RJ, Bendell DJ, Garnett I, Groundwater PW, Lough WJ, Mills MJ, Savery D, Shattock PE.

Institute of Pharmacy, Chemistry and Biomedical Sciences, University of Sunderland, UK. roz.anderson@sunderland.ac.uk

HPLC analysis of the urine of autistic subjects indicated the presence of an unidentified component in greatly increased concentrations. We have reported the isolation of this component by HPLC and its identification. Mass spectrometry, NMR and UV spectroscopy identified the peak as corresponding to indolyl-3-acryloylglycine (IAG, 3), and this has been confirmed by an independent synthesis.

PMID: 11858215 [PubMed - indexed for MEDLINE]