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Yonsei Med J. 2002 Feb;43(1):114-8.

Acute renal failure associated with a minimal change nephrotic syndrome in a systemic lupus erythematosus patient.

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  • 1Division of Nephrology and Hypertension, Department of Internal Medicine, Inha University College of Medicine, Inchon, Korea.


In systemic lupus erythematosus (SLE), acute renal failure (ARF) is usually associated with severe lupus nephritis and ARF associated with other glomerular diseases is extremely rare. We recently encountered a patient with ARF that was associated with a minimal change nephrotic syndrome (MCNS) in SLE. A 41-year-old woman presented with a nephrotic syndrome and ARF. She fulfilled four of the American College of Rheumatology criteria for the classification of SLE. However, a renal biopsy revealed that there were no glomerular abnormalities and no deposition of immune complex. The generalized edema disappeared and the high creatinine levels decreased after prednisolone therapy.

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