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Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome.
Sapkota GP, Boudeau J, Deak M, Kieloch A, Morrice N, Alessi DR.
Biochem J. 2002 Mar 1;362(Pt 2):481-90.
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Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth.
Sapkota GP, Kieloch A, Lizcano JM, Lain S, Arthur JS, Williams MR, Morrice N, Deak M, Alessi DR.
J Biol Chem. 2001 Jun 1;276(22):19469-82. Epub 2001 Jan 31.
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