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Nat Genet. 2002 Mar;30(3):255-6. Epub 2002 Feb 19.

A gene-driven approach to the identification of ENU mutants in the mouse.

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  • 1MRC Mammalian Genetics Unit and UK Mouse Genome Centre, Harwell OX11 ORD, UK.


The construction of parallel archives of DNA and sperm from mice mutagenized with ethylnitrosurea (ENU) represents a potentially powerful and rapid approach for identifying point mutations in any gene in the mouse genome. We provide support for this approach and report the identification of mutations in the gene (Gjb2) encoding connexin 26, using archives established from the UK ENU mutagenesis program.

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