Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Interferon Cytokine Res. 2002 Jan;22(1):5-14.

Activities of IRF-1.

Author information

  • 1Department of Gene Regulation and Differentiation, GBF, Gesellschaft für Biotechnologische Forschung, D 38124 Braunschweig Mascheroder Weg 1, Germany.

Abstract

Interferon (IFN) regulatory factor-1 (IRF-1) was isolated by virtue of its affinity to specific DNA sequences in the IFN-beta promoter that mediate virus responsiveness. IRF-1 was the first factor identified of the IRF family and was most extensively characterized at the molecular level. Also, its physiologic role in host defense against pathogens, tumor prevention, and development of the immune system was investigated in detail. Even though some of the functions first associated with IRF-1 were later found to be mediated in part or predominantly by other activators of the IRF family of transcription factors, IRF-1 has remained a central paradigm in the transcriptional regulation of the IFN response.

PMID:
11846971
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Mary Ann Liebert, Inc.
    Loading ...
    Write to the Help Desk