Pflugers Arch. 2001;443 Suppl 1:S107-10. Epub 2001 Jul 21.

Ca(2+)-activated Cl(-) channels: a newly emerging anion transport family.

Fuller CM, Ji HL, Tousson A, Elble RC, Pauli BU, Benos DJ.

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Department of Physiology and Biophysics, University of Alabama at Birmingham, MCLM 830, 1918 University Boulevard, Birmingham, AL 35294, USA. fuller@physiology.uab.edu

Abstract

A new family of chloride transport proteins has recently emerged. These proteins have extensive homology to a protein previously isolated from bovine tracheal epithelium that acts as a Ca(2+)-sensitive Cl(-) channel (CaCC) when heterologously expressed or when reconstituted into planar lipid bilayers. Several new members of this family have been identified in human, murine, and bovine epithelia, in addition to some other tissues, and are associated with Ca(2+)-sensitive conductive chloride transport when heterologously expressed in Xenopus oocytes or HEK 293 cells. The expressed current is also sensitive to inhibitors such as DIDS and niflumic acid. In addition, at least one family member acts as an endothelial cell adhesion molecule. This emerging family may underlie the Ca(2+)-mediated Cl(-) conductance responsible for rescue of the cystic fibrosis (CF) knockout mouse from significant airway disease.

PMID:: 11845314; [PubMed - indexed for MEDLINE]

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