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Bioorg Med Chem Lett. 2002 Feb 25;12(4):697-9.

Benzylidene rhodanines as novel inhibitors of UDP-N-acetylmuramate/L-alanine ligase.

Author information

  • 1Medicinal and Combinatorial Chemistry Laboratory, Institute of Molecular and Cell Biology, 30Medical Drive, 117609, Singapore, Singapore. mcbsimmm@imcb.nus.edu.sg

Abstract

Benzylidene rhodanines are novel inhibitors of UDP N-acetylmuramate/L-alanine ligase. They showed selective whole-cell activity against the Gram-positive MRSA but not against the Gram-negative Escherichia coli. Their cytotoxic effect on mammalian CHO cells was also evaluated.

PMID:
11844704
[PubMed - indexed for MEDLINE]
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