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Infect Control Hosp Epidemiol. 2001 Nov;22(11):697-700.

Transmission of hepatitis C in a pharmacologic study.

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  • 1Division of Infectious Diseases, Ottawa Hospital and the University of Ottawa, Ontario, Canada.

Abstract

OBJECTIVE:

To describe an outbreak of hepatitis C in a clinical research study.

DESIGN:

Observational study.

SETTING:

Tertiary-care hospital.

PATIENTS:

Healthcare workers who volunteered to be subjects in a study of the metabolic effects of inhaled and oral corticosteroids who were unwittingly exposed to hepatitis C virus (HCV).

METHODS:

Epidemiological investigation and serological analyses.

RESULTS:

One chronic carrier of HCV was identified. Four fellow workers volunteering in the studies became infected with HCV, with 96% homology among strains. There was no evidence of spread from infected healthcare workers to patients on whom they had performed arterial punctures (2 of 214 positive, unrelated to each other and to the outbreak strain).

CONCLUSION:

Infection control standards in clinical research must be maintained vigorously to prevent transmission of blood-borne pathogens such as HCV.

PMID:
11842990
[PubMed - indexed for MEDLINE]
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