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Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2450-4. Epub 2002 Feb 12.

Brain activity in ventromedial prefrontal cortex correlates with individual differences in negative affect.

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  • 1Department of Psychology, Vanderbilt University, 301 Wilson Hall, 111 21st Avenue South, Nashville, TN 37203, USA.

Abstract

Individuals differ in the extent to which they experience negative mood states over time. To explore the relationship between individual differences in negative affect (NA) and brain activity, we asked healthy subjects participating in positron-emission tomography scans to rate the extent to which they had experienced NA terms during the month before scanning. In two independent samples of subjects, resting regional cerebral blood flow within the ventromedial prefrontal cortex (VMPFC) correlated with ratings of NA. The finding converges with recent evidence implicating the VMPFC in emotional and autonomic processing. Moreover, it demonstrates that variability in basal VMPFC activity across subjects is related to individual differences in subjective emotional experience.

PMID:
11842195
[PubMed - indexed for MEDLINE]
PMCID:
PMC122385
Free PMC Article

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