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1: Insect Mol Biol. 2002 Feb;11(1):31-6.Click here to read Links

Identification and characterization of a Drosophila homologue of ATBP.

Aozasa N, Kubo T, Sekimizu K, Natori S.

Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan.

ATBP [(A+T)-stretch binding protein] activates the Sarcophaga defense protein genes in an (A+T)-stretch dependent manner as shown previously using a luciferase reporter assay [Aozasa et al. (2001) Eur J Biochem, 268, 2506-2511]. We identified the Drosophila homologue of ATBP. Drosophila ATBP has 388 amino acid residues and the amino acid sequence has high similarity with that of the Sarcophaga ATBP. In particular, residues 1-56 and 301-374 are highly conserved between Sarcophaga and Drosophila. Drosophila ATBP activated the Sarcophaga lectin gene promoter in SL-2 cells. The Drosophila ATBP gene is a single copy gene and is located in the 20E region of chromosome X.

PMID: 11841500 [PubMed - indexed for MEDLINE]