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Curr Opin Struct Biol. 2002 Feb;12(1):89-97.

Multisubunit RNA polymerases.

Author information

  • 1Institute of Biochemistry, Gene Center, University of Munich, Feodor-Lynen-Strasse 25, 81377, Munich, Germany. cramer@lmb.uni-muenchen.de

Abstract

Transcription of the genetic information in all cells is carried out by multisubunit RNA polymerases (RNAPs). Comparison of the crystal structures of a bacterial and a eukaryotic RNAP reveals a conserved core that comprises the active site and a multifunctional clamp. Together with a further structure of eukaryotic RNAP bound to DNA and RNA, these results elucidate many aspects of the transcription mechanism, including initiation, elongation, nucleotide addition, processivity and proofreading.

PMID:
11839495
[PubMed - indexed for MEDLINE]
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