Warning: The NCBI web site requires JavaScript to function. more...
Generate a file for use with external citation management software.
Department of Cellular and Molecular Pharmacology, Department of Biochemistry and Biophysics, University of California, San Francisco 94143-0450, USA. wlim@itsa.ucsf.edu
Many eukaryotic signal transduction proteins have component-based architectures: they are built from combinations of protein interaction domains and catalytic domains. Intact, these proteins display the sophisticated allosteric behavior required for cellular regulation; the protein's output activity is tightly repressed under basal conditions, but can be robustly activated by a specific set of input effector ligands. A combination of structural, biophysical and computational studies is beginning to shed light on the fundamental principles governing this type of modular allostery.
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on