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Nat Rev Neurosci. 2002 Feb;3(2):122-31.

Parallels between cerebellum- and amygdala-dependent conditioning.

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  • 1Howard Hughes Medical Institute, Department of Physiology, W.M. Keck Foundation Center for Integrative Neurobiology, University of California, 513 Parnassus Avenue, Room HSE-808, San Francisco, California 94143-0444, USA. jmedina@phy.ucsf.edu

Erratum in

  • Nat Rev Neurosci 2002 Mar;3(3):236.

Abstract

Recent evidence from cerebellum-dependent motor learning and amygdala-dependent fear conditioning indicates that, despite being mediated by different brain systems, these forms of learning might use a similar sequence of events to form new memories. In each case, learning seems to induce changes in two different groups of neurons. Changes in the first class of cells are induced very rapidly during the initial stages of learning, whereas changes in the second class of cells develop more slowly and are resistant to extinction. So, anatomically distinct cell populations might contribute differentially to the initial encoding and the long-term storage of memory in these two systems.

PMID:
11836520
[PubMed - indexed for MEDLINE]
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