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Cell. 2002 Jan 25;108(2):153-64.

Apoptosis: a link between cancer genetics and chemotherapy.

Author information

  • 1Cancer Immunology Division, The Peter MacCallum Cancer Institute, Trescowthick Research Laboratories, Smorgon Family Building, St. Andrews Place, East Melbourne, 3002 Victoria, Australia. r.johnstone@pmci.unimelb.edu.au

Abstract

Defects in apoptosis underpin both tumorigenesis and drug resistance, and because of these defects chemotherapy often fails. Understanding the molecular events that contribute to drug-induced apoptosis, and how tumors evade apoptotic death, provides a paradigm to explain the relationship between cancer genetics and treatment sensitivity and should enable a more rational approach to anticancer drug design and therapy.

PMID:
11832206
[PubMed - indexed for MEDLINE]
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