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Cell. 2002 Jan 25;108(2):145-52.

Cancer as a complex genetic trait: tumor susceptibility in humans and mouse models.

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  • Comprehensive Cancer Center, Department of Biochemistry and Biophysics, 2340 Sutter Street, University of California San Francisco, San Francisco, CA 94143, USA. abalmain@cc.ucsf.edu


Cancer directly affects at least one-third of the human population, but the inherited genetic determinants of cancer risk remain largely unknown. Mouse models of human cancer are helping us to understand this disease as a complex genetic trait and thus to identify the multiple genetic variant alleles involved in pathways that affect individual cancer susceptibility.

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