Peptide YY and cancer: current findings and potent...[Peptides. 2002]

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1: Peptides. 2002 Feb;23(2):389-95. Links

Peptide YY and cancer: current findings and potential clinical applications.

Tseng WW, Liu CD.

Northwestern University Medical School, Chicago, Illinois 60611, USA.

Peptide YY (PYY) is a naturally occurring gut hormone with mostly inhibitory actions on multiple tissue targets. PYY has been identified in several carcinoid tumors and a decreased expression of PYY may be relevant to the development and progression of colon adenocarcinoma. Treatment with PYY decreases growth in pancreatic and breast tumors, most likely through a reduction in intracellular cAMP. In cancer patients, PYY may also improve malnutrition that results from iatrogenic causes or cachexia associated with advanced disease. PYY plays a significant role in multiple aspects of cancer from regulation of cell growth to potential therapeutic applications.

PMID: 11825654 [PubMed - indexed for MEDLINE]

Peptide YY inhibits growth of human breast cancer in vitro and in vivo.
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[J Surg Res. 1999]
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Surgery. 1995 Aug; 118(2):229-35; discussion 235-6.

[Surgery. 1995]
Synthetic peptide YY analog binds to a cell membrane receptor and delivers fluorescent dye to pancreatic cancer cells.
J Gastrointest Surg. 2001 Mar-Apr; 5(2):147-52.

[J Gastrointest Surg. 2001]
ReviewPYY and the pancreas: inhibition of tumor growth and inflammation.
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ReviewGut hormones as peripheral anti obesity targets.
Curr Drug Targets CNS Neurol Disord. 2004 Oct; 3(5):379-88.

[Curr Drug Targets CNS Neurol Disord. 2004]
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Cited by 1 PubMed Central article

Alternative splicing and differential gene expression in colon cancer detected by a whole genome exon array.
Gardina PJ, Clark TA, Shimada B, Staples MK, Yang Q, Veitch J, Schweitzer A, Awad T, Sugnet C, Dee S, et al. BMC Genomics. 2006 Dec 27; 7:325. Epub 2006 Dec 27.

[BMC Genomics. 2006]

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