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    Peptides. 2002 Feb;23(2):389-95.

    Peptide YY and cancer: current findings and potential clinical applications.

    Tseng WW, Liu CD.

    Northwestern University Medical School, Chicago, Illinois 60611, USA.

    Peptide YY (PYY) is a naturally occurring gut hormone with mostly inhibitory actions on multiple tissue targets. PYY has been identified in several carcinoid tumors and a decreased expression of PYY may be relevant to the development and progression of colon adenocarcinoma. Treatment with PYY decreases growth in pancreatic and breast tumors, most likely through a reduction in intracellular cAMP. In cancer patients, PYY may also improve malnutrition that results from iatrogenic causes or cachexia associated with advanced disease. PYY plays a significant role in multiple aspects of cancer from regulation of cell growth to potential therapeutic applications.

    PMID: 11825654 [PubMed - indexed for MEDLINE]

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