J Nutr. 2002 Feb;132(2):257-60.

The daily oral administration of high doses of trans-resveratrol to rats for 28 days is not harmful.

Source

Departament de Fisiologia-Divisió IV, Facultat de Farmàcia, Universitat de Barcelona, E-08028 Barcelona, Spain.

Abstract

trans-3,5,4'-Trihydroxystilbene (trans-resveratrol) is a phytochemical present in peanuts, grapes and wine with beneficial effects such as protection against cardiovascular disease and cancer prevention. The purpose of this study was to evaluate whether high doses of trans-resveratrol have harmful effects on Sprague-Dawley rats. trans-Resveratrol was administered orally to male rats for 28 d at a dose of 20 mg/(kg x d), 1000 times the amount consumed by a 70-kg person taking 1.4 g of trans-resveratrol/d. Body weight, and food and water consumption did not differ between rats treated with trans-resveratrol and the control group. Hematologic and biochemical variables were not affected by the treatment. Histopathologic examination of the organs obtained at autopsy did not reveal any alterations. These results support the view that repeated consumption of trans-resveratrol at 20 mg/(kg x d) does not adversely affect the variables tested in rats.

PMID:: 11823587; [PubMed - indexed for MEDLINE]

Free full text

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Resveratrol toxicity: effects on risk factors for atherosclerosis and hepatic oxidative stress in standard and high-fat diets. [Food Chem Toxicol. 2009]
Resveratrol toxicity: effects on risk factors for atherosclerosis and hepatic oxidative stress in standard and high-fat diets.
Rocha KK, Souza GA, Ebaid GX, Seiva FR, Cataneo AC, Novelli EL. Food Chem Toxicol. 2009 Jun; 47(6):1362-7. Epub 2009 Mar 17.
trans-Resveratrol, a natural antioxidant from grapes, increases sperm output in healthy rats. [J Nutr. 2005]
trans-Resveratrol, a natural antioxidant from grapes, increases sperm output in healthy rats.
Juan ME, González-Pons E, Munuera T, Ballester J, Rodríguez-Gil JE, Planas JM. J Nutr. 2005 Apr; 135(4):757-60.
Plant foods and herbal sources of resveratrol. [J Agric Food Chem. 2002]
Plant foods and herbal sources of resveratrol.
Burns J, Yokota T, Ashihara H, Lean ME, Crozier A. J Agric Food Chem. 2002 May 22; 50(11):3337-40.
Review Potential of resveratrol in anticancer and anti-inflammatory therapy. [Nutr Rev. 2008]
Review Potential of resveratrol in anticancer and anti-inflammatory therapy.
Udenigwe CC, Ramprasath VR, Aluko RE, Jones PJ. Nutr Rev. 2008 Aug; 66(8):445-54.
Review Wine, resveratrol and health: a review. [Nat Prod Commun. 2009]
Review Wine, resveratrol and health: a review.
Guerrero RF, García-Parrilla MC, Puertas B, Cantos-Villar E. Nat Prod Commun. 2009 May; 4(5):635-58.

See reviews... See all...

Cited by 11 PubMed Central articles

Resveratrol suppresses human colon cancer cell proliferation and induces apoptosis via targeting the pentose phosphate and the talin-FAK signaling pathways-A proteomic approach. [Proteome Sci. 2011]
Resveratrol suppresses human colon cancer cell proliferation and induces apoptosis via targeting the pentose phosphate and the talin-FAK signaling pathways-A proteomic approach.
Vanamala J, Radhakrishnan S, Reddivari L, Bhat VB, Ptitsyn A. Proteome Sci. 2011 Aug 17; 9(1):49. Epub 2011 Aug 17.
Review What is new for an old molecule? Systematic review and recommendations on the use of resveratrol. [PLoS One. 2011]
Review What is new for an old molecule? Systematic review and recommendations on the use of resveratrol.
Vang O, Ahmad N, Baile CA, Baur JA, Brown K, Csiszar A, Das DK, Delmas D, Gottfried C, Lin HY, et al. PLoS One. 2011; 6(6):e19881. Epub 2011 Jun 16.
Dose-dependency of resveratrol in providing health benefits. [Dose Response. 2010]
Dose-dependency of resveratrol in providing health benefits.
Mukherjee S, Dudley JI, Das DK. Dose Response. 2010 Mar 18; 8(4):478-500. Epub 2010 Mar 18.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The daily oral administration of high doses of trans-resveratrol to rats for 28 ...
The daily oral administration of high doses of trans-resveratrol to rats for 28 days is not harmful.
J Nutr. 2002 Feb ;132(2):257-60.

PubMed
Assembly and iron-binding properties of human frataxin, the protein deficient in...
Assembly and iron-binding properties of human frataxin, the protein deficient in Friedreich ataxia.
Hum Mol Genet. 2002 Feb 1 ;11(3):217-27.

PubMed
Vascular basis of late-onset depressive disorder.
Vascular basis of late-onset depressive disorder.
Br J Psychiatry. 2002 Feb ;180:157-60.

PubMed
A factor analysis of tic symptoms in Gilles de la Tourette's syndrome.
A factor analysis of tic symptoms in Gilles de la Tourette's syndrome.
Am J Psychiatry. 2002 Feb ;159(2):291-6.

PubMed
Functional impairment in patients with schizotypal, borderline, avoidant, or obs...
Functional impairment in patients with schizotypal, borderline, avoidant, or obsessive-compulsive personality disorder.
Am J Psychiatry. 2002 Feb ;159(2):276-83.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

The daily oral administration of high doses of trans-resveratrol to rats for 28 days is not harmful.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 11 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information