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J Immunol. 2002 Feb 15;168(4):1533-7.

Cutting edge: Immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent.

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  • 1Department of Medicine, Division of Infectious Diseases, Boston University School of Medicine, Boston, MA 02118, USA.


The immunopotentiating activity of neisserial porins, the major outer membrane protein of the pathogenic Neisseria, is mediated by its ability to stimulate B cells and up-regulate the surface expression of B7-2. This ability is dependent on MyD88 and Toll-like receptor (TLR)2 expression, as demonstrated by a lack of a response by B cells from MyD88 or TLR2 knockout mice to the porins. Using previously described TLR2-dependent reporter constructs, these results were confirmed and were shown to be due to induction of NF-kappaB nuclear translocation. This is the first demonstration of known vaccine adjuvant to stimulate immune cells via TLR2.

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