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J Immunol. 2002 Feb 15;168(4):1524-7.

Cutting edge: Transcriptional activity of NFATc1 is enhanced by the Pim-1 kinase.

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  • 1Turku Centre for Biotechnology, University of Turku/Abo Akademi University, and Turku Graduate School of Biomedical Sciences, Turku, Finland.

Abstract

Pim-1 is an oncogenic serine/threonine kinase implicated in cytokine-induced signal transduction and in development of lymphoid malignancies. However, its precise function as well as physiological substrates have remained unknown. In this study we demonstrate that Pim-1 can physically interact with the NFATc1 transcription factor and phosphorylate it in vitro on several serine residues. In contrast to previously recognized NFATc kinases, wild-type Pim-1 enhances NFATc-dependent transactivation and IL-2 production in Jurkat T cells, while kinase-deficient Pim-1 mutants inhibit them in a dominant negative fashion. Our results reveal a novel, phosphorylation-dependent regulatory mechanism targeting NFATc1 through which Pim-1 acts as a downstream effector of Ras to facilitate IL-2-dependent proliferation and/or survival of lymphoid cells.

PMID:
11823475
[PubMed - indexed for MEDLINE]
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