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Am J Psychiatry. 2002 Feb;159(2):309-12.

Unaltered dopamine transporter availability in adult attention deficit hyperactivity disorder.

Author information

  • 1Department of Psychiatry, Yale University School of Medicine, Cognitive Disorders Clinic, New Haven, CT 06510, USA. christopher.vandyck@yale.edu

Abstract

OBJECTIVE:

The authors examined whether patients with attention deficit hyperactivity disorder (ADHD) have altered striatal dopamine transporter levels, which may explain psychostimulant effects in this disorder.

METHOD:

Single photon emission computed tomography and [(123)I]2beta-carbomethoxy-3beta-(4-iodophenyl)tropane ([(123)I]beta-CIT) were used to assess dopamine transporter availability in nine adult patients with ADHD (eight of whom were stimulant naive) and nine age- and gender-matched healthy comparison subjects.

RESULTS:

Striatal [(123)I]beta-CIT binding did not differ significantly between the ADHD and comparison subjects.

CONCLUSIONS:

The findings suggest that a hypothesized dysregulation of dopamine function in ADHD does not entail altered dopamine transporter levels.

PMID:
11823278
[PubMed - indexed for MEDLINE]
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