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Oncogene. 2002 Jan 17;21(3):437-46.

E2Fs up-regulate expression of genes involved in DNA replication, DNA repair and mitosis.

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  • 1Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.


The E2F family of transcription factors plays a pivotal role in the regulation of cell proliferation in higher eukaryotes. We used DNA microarrays and cell lines containing either inducible E2F-1 or inducible E2F-3 to identify novel E2F target genes. Our data indicate that E2F up-regulates the expression of genes not previously described as E2F target genes. A number of these E2F-regulated genes are involved in DNA replication, DNA repair and mitosis. These results suggest that E2F affects cell cycle progression both at S phase and during mitosis. Furthermore, our findings indicate that E2F-dependent gene activation may contribute to the cellular response to DNA damage.

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