Your browser version may not work well with NCBI's Web applications. More information here...
1: News Physiol Sci. 2002 Feb;17:32-7.Click here to read Links

From funny current to HCN channels: 20 years of excitation.

Accili EA, Proenza C, Baruscotti M, DiFrancesco D.

. School of Kinesiology, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.

The "funny" (pacemaker) current has unusual characteristics, including activation on hyperpolarization, permeability to K(+) and Na(+), modulation by internal cAMP, and a tiny, single-channel conductance. In cardiac cells and neurons, pacemaker channels control repetitive activity and excitability. The recent cloning of HCN subunits provides new insight into the molecular basis for the funny channel properties.

PMID: 11821534 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Potassium (Glu-K® , K+ 10® , K+ 8® , ...)

    Potassium is essential for the proper functioning of the heart, kidneys, muscles, nerves, and digestive system. Usually the food you eat supplies all of the potassium you need. However, certain diseases (e.g., kidney dis...

  • Source: AHFS Consumer Medication Information