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Trends Genet. 2002 Feb;18(2):74-82.

Genome architecture, rearrangements and genomic disorders.

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  • 1Dept Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030-3498, USA.

Abstract

An increasing number of human diseases are recognized to result from recurrent DNA rearrangements involving unstable genomic regions. These are termed genomic disorders, in which the clinical phenotype is a consequence of abnormal dosage of gene(s) located within the rearranged genomic fragments. Both inter- and intrachromosomal rearrangements are facilitated by the presence of region-specific low-copy repeats (LCRs) and result from nonallelic homologous recombination (NAHR) between paralogous genomic segments. LCRs usually span approximately 10-400 kb of genomic DNA, share >or= 97% sequence identity, and provide the substrates for homologous recombination, thus predisposing the region to rearrangements. Moreover, it has been suggested that higher order genomic architecture involving LCRs plays a significant role in karyotypic evolution accompanying primate speciation.

PMID:
11818139
[PubMed - indexed for MEDLINE]
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