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Trends Neurosci. 2002 Feb;25(2):108-15.

Gap junctions and motor behavior.

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  • 1Dept of Neuroscience, Karolinska Institutet, Retzius Vag 8, S-171 77, Stockholm, Sweden. Ole.Kiehn@neuro.ki.se

Abstract

The production of any motor behavior requires coordinated activity in motor neurons and premotor networks. In vertebrates, this coordination is often assumed to take place through chemical synapses. Here we review recent data suggesting that electrical gap-junction coupling plays an important role in coordinating and generating motor outputs in embryonic and early postnatal life. Considering the recent demonstration of a prevalent expression of gap-junction proteins and gap-junction structures in the adult mammalian spinal cord, we suggest that neuronal gap-junction coupling might also contribute to the production of motor behavior in adult mammals.

PMID:
11814564
[PubMed - indexed for MEDLINE]
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