Association study of the p53-gene Pro72Arg polymorphism in schizophrenia

Psychiatry Res. 2001 Dec 31;105(3):279-83. doi: 10.1016/s0165-1781(01)00328-6.

Abstract

The p53 tumor-suppressor gene, encoding a phosphoprotein, is a key element in maintaining genomic stability and cell apoptosis. It is also implicated in nervous-system development. In order to examine the role of the p53 gene for the pathogenesis of schizophrenic disorders, patients (n=155) and control subjects (n=168) were genotyped for the p53-Pro72Arg polymorphism. The results demonstrated no association with schizophrenia and/or age of onset for this polymorphism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Female
  • Gene Expression / genetics*
  • Gene Frequency / genetics
  • Genes, p53 / genetics*
  • Humans
  • Male
  • Polymerase Chain Reaction
  • Polymorphism, Genetic / genetics*
  • Schizophrenia / genetics*