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Cerebrovasc Dis. 2002;13(1):43-6.

Incidence of adult brain arteriovenous malformation hemorrhage in a prospective population-based stroke survey.

Author information

  • 1Stroke Center/The Neurological Institute, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. christian.stapf@medizin.fu-berlin.de

Abstract

BACKGROUND:

Brain arteriovenous malformations (AVMs) represent a potential source of intracranial hemorrhage, especially in young adults, but prospective population-based incidence data on AVM hemorrhage are lacking. We investigated the incidence of first-ever AVM hemorrhage in adults based on population data from the Northern Manhattan Stroke Study (NOMASS).

METHODS:

NOMASS is a prospective, population-based, stroke incidence survey collecting all hospitalized and nonhospitalized cases with first-ever (incident) stroke over the age of 20 in a ZIP code-defined area. All patients undergo CT and/or MR brain imaging and clinical data are systematically collected from the medical records. For this study, data on all cases with incident intracranial hemorrhage, i.e. any intracerebral, intraventricular and/or subarachnoid hemorrhage, occurring between July 1, 1993 and June 30, 1997 were used. Patients with intracranial hemorrhage due to trauma, tumor or intracranial vascular malformations other than a previously unknown AVM were excluded from the study.

RESULTS:

Of the 207 patients diagnosed with a first-ever intracranial hemorrhage, 3 cases (1.4%) with an underlying brain AVM were identified. The crude incidence rate for first-ever AVM hemorrhage in our adult population was 0.55 per 100,000 person-years (95% confidence interval 0.11-1.61).

CONCLUSIONS:

Our results support prior findings from retrospective surveys. Population-based studies providing a prospective design for AVM detection and diagnosis are needed to confirm the data.

Copyright 2002 S. Karger AG, Basel

PMID:
11810010
[PubMed - indexed for MEDLINE]
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