Biochim Biophys Acta. 1975 Oct 20;405(2):412-21.

Characterization of the collagen of human hypertrophic and normal scars.

Bailey AJ, Bazin S, Sims TJ, Le Lous M, Nicoletis C, Delaunay A.

Abstract

The collagen produced in response to an injury of human skin is initially stabilized by a cross-link derived from hydroxyallysine, and characteristic of embryonic skin. In normal healing there is a change over with time to the cross-link derived from allysine, which is typical of young skin collagen. In contrast, hypertrophic scars fail to follow the time-related changes of normal skin, but retain the characteristics of embryonic collagen, indicating a continued rapid turnover of the collagen. This is further supported by the high proportion of the embryonic Type III collagen present in hypertrophic scars.

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Characterization of the collagen of human hypertrophic and normal scars.

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