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Characterization of the collagen of human hypertrophic and normal scars.
The collagen produced in response to an injury of human skin is initially stabilized by a cross-link derived from hydroxyallysine, and characteristic of embryonic skin. In normal healing there is a change over with time to the cross-link derived from allysine, which is typical of young skin collagen. In contrast, hypertrophic scars fail to follow the time-related changes of normal skin, but retain the characteristics of embryonic collagen, indicating a continued rapid turnover of the collagen. This is further supported by the high proportion of the embryonic Type III collagen present in hypertrophic scars.
PMID: 1180964 [PubMed - indexed for MEDLINE]
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Cited by 12 PubMed Central articles
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Collagen type I and III synthesis by Tenon's capsule fibroblasts in culture: individual patient characteristics and response to mitomycin C, 5-fluorouracil, and ascorbic acid.
Gross RL.
Trans Am Ophthalmol Soc. 1999; 97:513-43.
[Trans Am Ophthalmol Soc. 1999]
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Lysylhydroxylation and non-reducible crosslinking of human supraspinatus tendon collagen: changes with age and in chronic rotator cuff tendinitis.
Bank RA, TeKoppele JM, Oostingh G, Hazleman BL, Riley GP.
Ann Rheum Dis. 1999 Jan; 58(1):35-41.
[Ann Rheum Dis. 1999]
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Defective collagen crosslinking in bone, but not in ligament or cartilage, in Bruck syndrome: indications for a bone-specific telopeptide lysyl hydroxylase on chromosome 17.
Bank RA, Robins SP, Wijmenga C, Breslau-Siderius LJ, Bardoel AF, van der Sluijs HA, Pruijs HE, TeKoppele JM.
Proc Natl Acad Sci U S A. 1999 Feb 2; 96(3):1054-8.
[Proc Natl Acad Sci U S A. 1999]
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