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1: Respir Res. 2002;3:8. Epub 2001 Nov 19.Click here to read Click here to read Links

The relationship between FV Leiden and pulmonary embolism.

Hooper WC, De Staercke C.

Hematologic Disease Branch, Division of AIDS, STD, and TB Laboratory Research, National Centers for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, USA. chooper@cdc.gov

Pulmonary embolism (PE) is one of the leading causes of in-patient hospital deaths. As a consequence, the identification of hemostatic variables that could identify those at risk would be important in reducing mortality. It has previously been thought that deep vein thrombosis and PE are a single disease entity and would, therefore, have the same risk factors. This view is changing, however, with the realization that the prevalence of FV Leiden, a recognized genetic risk factor for deep vein thrombosis, may be a 'milder' genetic risk factor for PE. These observations suggest that PE is not only associated with a different set of risk factors, but may be reflective of a different clot structure.

PMID: 11806843 [PubMed - indexed for MEDLINE]

PMCID: PMC64819

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