Evolution of the initiating enzymes of the complem...[Genome Biol. 2002]

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1: Genome Biol. 2002;3(1):REVIEWS1001. Epub 2001 Dec 14. Links

Evolution of the initiating enzymes of the complement system.

Nonaka M, Miyazawa S.

Department of Biological Sciences, Graduate School of Science, University of Tokyo, Hongo, Tokyo 113-0033, Japan. mnonaka@biol.s.u-tokyo.ac.jp

Analysis of the human MASP-1/3 gene, which encodes two proteases of the lectin-triggered complement cascade, has revealed alternatively used serine-protease-encoding regions for the gene's two protein products. Phylogenetic studies indicate that one arose by retrotransposition early in vertebrate evolution, supporting the idea that the lectin branch of the complement cascade arose earlier than the 'classical' pathway.

PMID: 11806831 [PubMed - indexed for MEDLINE]

PMCID: PMC150455

Origin of mannose-binding lectin-associated serine protease (MASP)-1 and MASP-3 involved in the lectin complement pathway traced back to the invertebrate, amphioxus.
J Immunol. 2003 May 1; 170(9):4701-7.

[J Immunol. 2003]
The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3.
Genes Immun. 2001 May; 2(3):119-27.

[Genes Immun. 2001]
ReviewThe mannan-binding lectin-associated serine proteases (MASPs) and MAp19: four components of the lectin pathway activation complex encoded by two genes.
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Two lineages of mannose-binding lectin-associated serine protease (MASP) in vertebrates.
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[J Immunol. 1998]
ReviewStructural and functional aspects of complement activation by mannose-binding protein.
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[Immunobiology. 2002]
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