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J Chemother. 2001 Dec;13(6):611-4.

Bactericidal activity of Pistacia lentiscus mastic gum against Helicobacter pylori.

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  • 1Laboratorio di Batteriologia e Micologia--Area Infettivologica, IRCCS S. Matteo, Pavia, Italy. pmarone@smatteo.pv.it

Abstract

In this study we evaluated the antibacterial activity of mastic gum, a resin obtained from the Pistacia lentiscus tree, against clinical isolates of Helicobacter pylori. The minimal bactericidal concentrations (MBCs) were obtained by a microdilution assay. Mastic gum killed 50% of the strains tested at a concentration of 125 microg/ml and 90% at a concentration of 500 microg/ml. The influence of sub-MBCs of mastic gum on the morphologies of H. pylori was evaluated by transmission electron microscopy. The lentiscus resin induced blebbing, morphological abnormalities and cellular fragmentation in H. pylori cells.

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