Nature. 2002 Jan 10;415(6868):219-26.

New ideas about atrial fibrillation 50 years on.

Source

Department of Medicine, Montreal Heart Institute Research Center, Quebec, Canada. nattel@icm.umontreal.ca

Abstract

Atrial fibrillation is a condition in which control of heart rhythm is taken away from the normal sinus node pacemaker by rapid activity in different areas within the upper chambers (atria) of the heart. This results in rapid and irregular atrial activity and, instead of contracting, the atria only quiver. It is the most common cardiac rhythm disturbance and contributes substantially to cardiac morbidity and mortality. For over 50 years, the prevailing model of atrial fibrillation involved multiple simultaneous re-entrant waves, but in light of new discoveries this hypothesis is now undergoing re-evaluation.

PMID:: 11805846; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

Review

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Atrial Fibrillation - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Review Rate versus rhythm control in patients with atrial fibrillation: what the trials really say. [Drugs. 2005]
Review Rate versus rhythm control in patients with atrial fibrillation: what the trials really say.
Crijns HJ. Drugs. 2005; 65(12):1651-67.
Electrophysiological evaluation of the sinus node and the cardiac conduction system following the maze procedure for atrial fibrillation. [Pacing Clin Electrophysiol. 2004]
Electrophysiological evaluation of the sinus node and the cardiac conduction system following the maze procedure for atrial fibrillation.
Albåge A, Lindblom D, Insulander P, Kennebäck G. Pacing Clin Electrophysiol. 2004 Feb; 27(2):194-203.
Evaluation of bilateral pulmonary vein isolation for the treatment of atrial fibrillation: value of postoperative electrophysiological study. [Rev Port Cardiol. 2002]
Evaluation of bilateral pulmonary vein isolation for the treatment of atrial fibrillation: value of postoperative electrophysiological study.
Adragão P, Queirós e Melo J, Aguiar C, Teles R, Cavaco D, Neves J, Abecasis M, Ribeiras R, Bonhorst D, Seabra-Gomes R. Rev Port Cardiol. 2002 Nov; 21(11):1281-93.
Pulmonary vein dimensions and variation of branching pattern in patients with paroxysmal atrial fibrillation using magnetic resonance angiography. [Jpn Heart J. 2004]
Pulmonary vein dimensions and variation of branching pattern in patients with paroxysmal atrial fibrillation using magnetic resonance angiography.
Takase B, Nagata M, Matsui T, Kihara T, Kameyama A, Hamabe A, Noya K, Satomura K, Ishihara M, Kurita A, et al. Jpn Heart J. 2004 Jan; 45(1):81-92.
Review Biological therapies for atrial fibrillation. [J Cardiovasc Pharmacol. 2008]
Review Biological therapies for atrial fibrillation.
Amit G, Qin H, Donahue JK. J Cardiovasc Pharmacol. 2008 Sep; 52(3):222-7.

See reviews... See all...

Cited by 75 PubMed Central articles

Mutations in the potassium channel subunit KCNE1 are associated with early-onset familial atrial fibrillation. [BMC Med Genet. 2012]
Mutations in the potassium channel subunit KCNE1 are associated with early-onset familial atrial fibrillation.
Olesen MS, Bentzen BH, Nielsen JB, Steffensen AB, David JP, Jabbari J, Jensen HK, Haunsø S, Svendsen JH, Schmitt N. BMC Med Genet. 2012 Apr 3; 13:24. Epub 2012 Apr 3.
Loss of proteostatic control as a substrate for atrial fibrillation: a novel target for upstream therapy by heat shock proteins. [Front Physiol. 2012]
Loss of proteostatic control as a substrate for atrial fibrillation: a novel target for upstream therapy by heat shock proteins.
Meijering RA, Zhang D, Hoogstra-Berends F, Henning RH, Brundel BJ. Front Physiol. 2012; 3:36. Epub 2012 Feb 23.
Recent clinical and experimental advances in atrial fibrillation. [ISRN Cardiol. 2011]
Recent clinical and experimental advances in atrial fibrillation.
Miyagawa S, Sakaguchi T, Nishi H, Yoshikawa Y, Fukushima S, Saito S, Sawa Y. ISRN Cardiol. 2011; 2011:958189. Epub 2011 Aug 1.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

New ideas about atrial fibrillation 50 years on.
New ideas about atrial fibrillation 50 years on.
Nature. 2002 Jan 10 ;415(6868):219-26.

PubMed
Systematic identification of protein complexes in Saccharomyces cerevisiae by ma...
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry.
Nature. 2002 Jan 10 ;415(6868):180-3.

PubMed
Protein complexes take the bait.
Protein complexes take the bait.
Nature. 2002 Jan 10 ;415(6868):123-4.

PubMed
Comparison of long-term functional and radiologic outcomes after Harrington inst...
Comparison of long-term functional and radiologic outcomes after Harrington instrumentation and spondylodesis in adolescent idiopathic scoliosis: a review of 78 patients.
Spine (Phila Pa 1976). 2002 Jan 15 ;27(2):176-80.

PubMed
Magnetic fields and miscarriage.
Magnetic fields and miscarriage.
Epidemiology. 2002 Jan ;13(1):1-4.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: