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Vaccine. 2002 Jan 15;20(7-8):1089-98.

Continuous antigen delivery from controlled release implants induces significant and anamnestic immune responses.

Author information

  • 1Centre for Animal Biotechnology, School of Veterinary Science, The University of Melbourne, Vic. 3010, Australia. j.kutyla@pgrad.unimelb.edu.au

Abstract

Two continuous delivery injectable silicone implants were tested to determine if they were capable of delivering vaccines in a single shot. The Type A implant delivers antigen in vitro over a 1-month-period and the Type B over several months. Vaccination studies in sheep were designed to compare the responses induced by the Type A and B implants, Alzet mini-osmotic pumps and conventional antigen delivery. A model antigen, avidin, was used along with IL-1beta or alum as adjuvants. Sheep were immunised with various formulations and the titre and isotype of the antigen specific antibodies monitored. The Type B implant induced antibody (Ab) titres of greater magnitude and duration than soluble vaccines or the Type A implant with adjuvant, but only if IL-1beta was included in the formulation. Both implants induced antibodies of IgG1 and IgG2 isotype. A memory response to soluble antigen challenge was induced by the Type B+IL-1beta implant, which was predominantly of an IgG1 isotype.

PMID:
11803069
[PubMed - indexed for MEDLINE]
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