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Trends Neurosci. 2002 Jan;25(1):8-10.

Cdk5 sinks into ALS.

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  • 1Dept of Pathology, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA.

Abstract

Recent research points to an involvement of deregulated cdk5 activity in the pathogenesis of mutant SOD1-mediated disease. In addition, inhibition of this activity might promote motor neuron survival. These observations have opened the door to further research into the role of cdk5 in ALS and other neurodegenerative diseases.

PMID:
11801324
[PubMed - indexed for MEDLINE]
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