Format

Send to

Choose Destination
See comment in PubMed Commons below
Ann N Y Acad Sci. 2001 Nov;944:373-87.

Beta cell replacement for the treatment of diabetes.

Author information

  • 1Department of Surgery, University Hospital, Geneva, Switzerland. celtrans@cmu.unige.ch

Abstract

The replacement of insulin-producing beta cells by islet transplantation can efficiently reverse diabetes. The recent improvements in clinical results were made possible by transplanting higher islet masses and through the introduction of new immunosuppressive protocols that avoid diabetogenicity. The need for alternatives to continuous immunosuppression, and an unlimited source of glucose-sensitive, insulin-secreting tissue, is emerging. In this review we discuss the various key steps in islet transplantation and offer perspectives for future developments in the replacement of insulin-producing beta cells for the treatment of type I diabetes.

PMID:
11797687
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Write to the Help Desk