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Trends Biochem Sci. 2002 Jan;27(1):1-3.

In the beginning: a viral origin exploits the cell.

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  • 1McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI 53706, USA.


The origin of replication of Epstein-Barr Virus (EBV) has been shown to associate with cellular proteins that regulate the initiation of DNA synthesis in human cells. These cellular proteins are subunits of both the origin recognition complex and what might be the replicative helicase. Such associations identify the EBV origin of replication as being an experimentally tractable paradigm for mammalian replicons.

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