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Ann N Y Acad Sci. 2001 Dec;952:88-108.

The future of colon cancer prevention.

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  • 1Gastrointestinal & Other Cancers Research Group, National Cancer Institute, Division of Cancer Prevention, EPN, Bethesda, Maryland 20892-7317, USA.


Chemoprevention science is in flux owing to rapid advances in postgenomic technology. We have witnessed enormous advances in the areas of early detection and molecular profiling of colorectal carcinogenesis; however, unique interpretive and technologic challenges persist. Neoplastic hallmarks must be iteratively tested and validated as markers of risk, targets for intervention, and/or markers of response in order to expedite the development of preventive interventions. In this review, we highlight several of the technologies that are revolutionizing our understanding of carcinogenesis and our approach to colorectal cancer prevention.

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