Catalytic oligonucleotides targeting EGR-1 as potential inhibitors of in-stent restenosis

Ann N Y Acad Sci. 2001 Dec:947:412-5. doi: 10.1111/j.1749-6632.2001.tb03975.x.

Abstract

This brief review discusses recent strategies targeting the zinc finger transcription factor and immediate-early gene product Egr-1 with catalytic DNA in efforts to inhibit postangioplasty restenosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Angioplasty, Balloon, Coronary*
  • Coronary Restenosis* / genetics
  • Coronary Restenosis* / prevention & control*
  • Coronary Restenosis* / therapy
  • DNA-Binding Proteins / genetics*
  • Early Growth Response Protein 1
  • Humans
  • Immediate-Early Proteins*
  • Stents*
  • Transcription Factors / genetics*

Substances

  • DNA-Binding Proteins
  • EGR1 protein, human
  • Early Growth Response Protein 1
  • Immediate-Early Proteins
  • Transcription Factors