Experience of treatment of disorders of peripheral blood circulation in 120 patients with diabetes mellitus was summarized. Conservative treatment, conducted in 85 patients, included insulinization, preparations of sulfanilurea and glibenclamids, antibacterial therapy (beta-lactams, aminoglycosides, metronidazole) during 7-10 days, acidum acetylsalicylicum, trental, solcoseryl, vitamins. Amputation of lower extremity was done 35 patients, in 15 of them--on the hip level. Good result was noted in the treatment of diabetic foot with pronounced trophic changes in the third stage of ischemia when fraxiparine was applied locally.