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1: Am J Trop Med Hyg. 2001 Dec;65(6):834-6.Click here to read Links

Helminth infections are associated with protection from malaria-related acute renal failure and jaundice in Thailand.

Nacher M, Singhasivanon P, Silachamroon U, Treeprasertsuk S, Vannaphan S, Traore B, Gay F, Looareesuwan S.

Unité INSERM 511, Immunobiologie Cellulaire et Moléculaire des Infections Parasitaires, Faculté de medecine Pitié-Salpétrière, Paris, France.

Following studies showing an association between helminth infections and protection from cerebral malaria, we compared 22 patients with malaria-associated acute renal failure with 157 patients with moderately severe malaria. Helminths were associated with protection from renal failure (adjusted odds ratio [AOR], 0.16 [0.03-0.85], P = 0.03). Helminth-infected controls were less likely to have jaundice (AOR, 0.39 [0.16-0.96], P = 0.04) or to have peripheral mature schizonts (AOR, 0.2 [0.07-0.62], P = 0.005) than controls without helminths. This suggested that preexisting helminth infections may have been protective by influencing sequestration and obstructive jaundice, 2 possible determinants of acute tubular necrosis.

PMID: 11791982 [PubMed - indexed for MEDLINE]