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Curr Opin Immunol. 2002 Feb;14(1):45-51.

Roles of heat-shock proteins in antigen presentation and cross-presentation.

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  • 1Center for Immunotherapy of Cancer and Infectious Diseases, MC 1601, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06030-1601, USA.


Heat-shock proteins chaperone antigenic peptides that are generated within cells. Such chaperoning is a part of the endogenous pathway of antigen presentation by MHC class I molecules. In addition, peptides that are chaperoned by heat-shock proteins, or are released by cell stress or death, are taken up by antigen-presenting cells and re-presented by their MHC molecules.

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