Nat Genet. 2002 Feb;30(2):141-2. Epub 2002 Jan 14.

Identification of foreign gene sequences by transcript filtering against the human genome.

Weber G, Shendure J, Tanenbaum DM, Church GM, Meyerson M.

Source

Department of Adult Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA.

Abstract

We have developed a computational subtraction approach to detect microbial causes for putative infectious diseases by filtering a set of human tissue-derived sequences against the human genome. We demonstrate the potential of this method by identifying sequences from known pathogens in established expressed-sequence tag libraries.

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Nat Genet. 2002 Feb;30(2):131-3.

PMID:: 11788827; [PubMed - indexed for MEDLINE]

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