Adv Exp Med Biol. 2000;483:157-62.

Hypotaurine protection on cell damage by singlet oxygen.

Pitari G, Duprè S, Spirito A, Antonini G, Amicarelli F.

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Dipartimento di Biologia di Base ed Applicata, Università di L'Aquila, Italy.

Abstract

Singlet oxygen (1O2), generated by irradiating methylene blue, is toxic to melanoma cell cultures. Hypotaurine is known to scavenge efficiently singlet oxygen; the addition of hypotaurine (800 microM) to the medium during irradiation of the dye produces a greater protective effect on cells than taurine added at the same concentration. The assay of some detoxifying enzymatic activities indicate a different mechanism of protection of the two molecules: taurine induces an efficient detoxifying enzymatic action with respect to the control; hypotaurine exerts its effect greatly by specifically scavenging singlet oxygen.

PMID:: 11787593; [PubMed - indexed for MEDLINE]

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