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Curr Opin Struct Biol. 2001 Oct;11(5):629-34.

Role of heparan sulfate in fibroblast growth factor signalling: a structural view.

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  • 1Department of Biochemistry, University of Cambridge, UK.


Fibroblast growth factors (FGFs) are among the best-studied heparin-binding proteins, and heparan sulfate proteoglycans regulate FGF signalling by direct molecular association with FGF and its tyrosine kinase receptor, FGFR. Two recently determined crystal structures of FGF-FGFR-heparin complexes have provided new structural information on how heparin binds to FGF and FGFR, and lead to different models for receptor dimerisation.

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