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Curr Opin Struct Biol. 2001 Oct;11(5):516-22.

Two-dimensional infrared spectroscopy: a promising new method for the time resolution of structures.

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  • 1Department of Chemistry, University of Pennsylvania, Philadelphia 19104-6323, USA. hochstra@sas.uppen.edu


Recently, new methods for determining time-evolving structures using infrared analogs of NMR spectroscopy have been introduced that have outstanding potential in structural biology. Already, within the past two years, structures of dipeptides, tripeptides and pentapeptides have been determined on much faster timescales than the conformational dynamics. Also, two-dimensional infrared correlation spectra of some proteins and isotopically edited alanine-rich helices have been examined.

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