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Dev Biol. 2001 Oct 1;238(1):202-12.

Dorsal pancreas agenesis in N-cadherin- deficient mice.

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  • 1Department of Medical Biochemistry, Box 440, Göteborg University, Göteborg, S-405 30, Sweden.


Members of the cadherin family of cell adhesion molecules are thought to be crucial regulators of tissue patterning and organogenesis. During pancreatic ontogeny N-cadherin is initially expressed in the pancreatic mesenchyme and later in pancreatic endoderm. Analysis of N-cadherin-deficient mice revealed that these mice suffer from selective agenesis of the dorsal pancreas. Further analysis demonstrated that the mechanism for the lack of a dorsal pancreas involves an essential function of N-cadherin as a survival factor in the dorsal pancreatic mesenchyme.

Copyright 2001 Academic Press.

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