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Blood Cells Mol Dis. 2001 Sep-Oct;27(5):830-43.

The bigger the C-value, the larger the cell: genome size and red blood cell size in vertebrates.

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  • 1Department of Zoology, University of Guelph, Guelph, Ontario N1G 2W1, Canada.


Vertebrate genome sizes vary roughly 350-fold and correlate with a variety of cellular and organismal parameters. Most notable among these is the relationship between genome size ("C-value") and red blood cell (RBC) size, which can be identified within and among each of the five vertebrate classes. This relationship, in turn, leads to important associations between genome size and features such as metabolic rate (at least in homeotherms). The present article describes the correlation between genome size and RBC size in vertebrates and discusses some of the cytological, physiological, and evolutionary implications of this relationship.

(c)2001 Elsevier Science.

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