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Acta Psychiatr Scand. 2001 Dec;104(6):411-22.

Post-traumatic stress disorder: a review of psychobiology and pharmacotherapy.

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  • 1Department of Psychiatry, Righospitalet, DK-2100 Copenhagen, Denmark.

Abstract

OBJECTIVE:

To review the literature on the psychobiology and pharmacotherapy of PTSD.

METHODS:

Relevant studies were identified by literature searches (Pub-med, Web of Science) and through reference lists. The search was ended by May 2001.

RESULTS:

There is evidence of involvement of opioid, glutamatergic, GABAergic, noradrenergic, serotonergic and neuroendocrine pathways in the pathophysiology of PTSD. Medications shown to be effective in double-blind placebo-controlled trials includes selective serotonin reuptake inhibitors, reversible and irreversible MAO-inhibitors, tricyclic antidepressants and the anticonvulsant lamotrigine. Still more agents appear promising in open-label trials.

CONCLUSION:

The complexity of the psychobiology is reflected by the difficulties in treating the disorder. According to the present knowledge, suggestions for drug treatment of PTSD are made.

PMID:
11782234
[PubMed - indexed for MEDLINE]
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