Format

Send to:

Choose Destination
See comment in PubMed Commons below
Ann Rheum Dis. 2002 Jan;61(1):29-31.

Familial systemic lupus erythematosus: the role of genetic and environmental factors.

Author information

  • 1Department of Medicine, Division of Allergy and Clinical Immunology, Tulane University School of Medicine, New Orleans, Louisiana, USA. geroglu@cs.com

Abstract

OBJECTIVE:

To examine the contribution of genetic and environmental factors to disease occurrence in 26 families with two or more members affected with systemic lupus erythematosus (SLE).

METHODS:

Genetic and environmental factors were examined by HLA-A, B, C/DR typing and by determining the presence of lymphocytotoxic antibodies (LCA) in patients and their consanguineous and non-consanguineous relatives.

RESULTS:

No association between SLE and HLA-A, B, C antigens was found. There was, however, a significant association with HLA-DR2 in white subjects with SLE. The most striking finding was that HLA sharing was increased among the affected members, suggesting genetic similarities. Seven of 14 sib pairs (50%) who had concordant SLE were HLA identical as opposed to an expected 25%. Another interesting finding was that 15/18 (83%) patients with SLE and 11/22 (50%) consanguineous relatives had LCA, while 1/9 (11%) spouses, and 2/42 (5%) healthy controls had these antibodies.

CONCLUSION:

Genetic factors have a role in the development and expression of SLE. Environmental factors may trigger the disease in genetically susceptible hosts.

PMID:
11779754
[PubMed - indexed for MEDLINE]
PMCID:
PMC1753892
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk