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Fertil Steril. 2002 Jan;77(1):91-7.

A nomogram to predict the probability of live birth after clomiphene citrate induction of ovulation in normogonadotropic oligoamenorrheic infertility.

Author information

  • 1Division of Reproductive Medicine, Rotterdam, The Netherlands.

Abstract

OBJECTIVE:

To establish whether initial screening characteristics of normogonadotropic anovulatory infertile women can aid in predicting live birth after induction of ovulation with clomiphene citrate (CC).

DESIGN:

Prospective longitudinal single-center study.

SETTING:

Specialist academic fertility unit.

PATIENT(S):

Two hundred fifty-nine couples with a history of infertility, oligoamenorrhea, and normal follicle-stimulating hormone (FSH) concentrations who have not been previously treated with any ovulation-induction medication.

INTERVENTION(S):

50, 100, or 150 mg of oral CC per day, for 5 subsequent days per cycle.

MAIN OUTCOME MEASURE(S):

Conception leading to live birth after CC administration.

RESULT(S):

After receiving CC, 98 (38%) women conceived, leading to live birth. The cumulative live birth rate within 12 months was 42% for the total study population and 56% for the ovulatory women who had received CC. Factors predicting the chances for live birth included free androgen index (testosterone/sex hormone-binding globulin ratio), body mass index, cycle history (oligomenorrhea versus amenorrhea), and the woman's age.

CONCLUSION(S):

It is possible to predict the individual chances of live birth after CC administration using two distinct prediction models combined in a nomogram. Applying this nomogram in the clinic may be a step forward in optimizing the decision-making process in the treatment of normogonadotropic anovulatory infertility. Alternative first line of treatment options could be considered for some women who have limited chances for success.

PMID:
11779596
[PubMed - indexed for MEDLINE]
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