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Science. 2002 Feb 8;295(5557):1089-92. Epub 2002 Jan 3.

Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning.

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  • 1Department of Animal Science, University of Missouri, Columbia, MO 65211, USA.


The presence of galactose alpha-1,3-galactose residues on the surface of pig cells is a major obstacle to successful xenotransplantation. Here, we report the production of four live pigs in which one allele of the alpha-1,3-galactosyltransferase locus has been knocked out. These pigs were produced by nuclear transfer technology; clonal fetal fibroblast cell lines were used as nuclear donors for embryos reconstructed with enucleated pig oocytes.

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